Water → 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine

Participants

Reaction Conditions

Reaction Steps

A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.

Provenance & Evidence