Fumaric Acid → HCID 9874450, compound

Participants

Reaction Steps

To a solution of (S)-(−)-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-[3-[N-methyl-N-[2-(3,4-methylenedioxy-phenoxy)ethyl]amino]propyl]-1,3-thiazolidin-4-one (569 mg, 1.05 mmol) in ethyl acetate (2 ml) was added a solution of fumaric acid (116 mg, 1.00 mmol) in methanol (3 ml) (prepared under preheating) and the mixture was stirred, then the solvent was removed under reduced pressure. The residue was dissolved in ethyl acetate (1 ml) under heating and the mixture was stirred at room temperature for 15 hours. The precipitate was filtered off, washed with ethyl acetate:n-hexane (1:1) and dried to give white crystals (582 mg). mp: 142-144° C.; Elementary analysis: calculated for C34H46N2O9: C, 61.99, H, 7.04, N, 4.25; found: C, 61.77, H, 7.09, N, 4.07.

Provenance & Evidence