1-Octanethiol → HCID 11141948, compound

Participants

Reaction Conditions

Reaction Steps

At 23° C., 17.6 g (0.1166 mol) of n-octanethiol were added with stirring over a period of 5 minutes to a mixture of 25 g (0.1132 mol) of 97.8% pure 2,3-dichloro-5-trifluoromethylpyridine and 7 mg (0.1 mol %) of copper powder, and the mixture was stirred at 185° C. for 4 h. After cooling, the reaction mixture was partitioned between methylene chloride and water and the organic phase was dried and concentrated. 35.4 g (96.1% of theory) of the title compound of 24 n D

Provenance & Evidence