Thiophenol → HCID 22450293, compound

HRID 636063Notes

Reaction equation

HRID 636063 reaction equation
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[C:9]1[C:14]([Cl:15])=[CH:13][C:12]([C:16]([F:19])([F:18])[F:17])=[CH:11][N:10]=1>[Cu]>[Cl:15][C:14]1[C:9]([S:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[N:10][CH:11]=[C:12]([C:16]([F:18])([F:17])[F:19])[CH:13]=1

Participants

4

Reactant 2

HCID 7969ThiophenolHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 22450293HCID 22450293, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 23978CopperCatalyst

Procedure

26 g (0.233 mol) of 98.7% pure thiophenol, 50 g (0.226 mol) of 97.8% pure 2,3-dichloro-5-trifluoromethylpyridine and 14.7 mg (0.23 mmol) of copper powder were reacted by the method of Example 1, except that the reaction time was only 1 h and the reaction temperature was 160-170° C. The yield was 99%.

Workup

  1. customwas 160-170° C

Sources & evidence

ORD record
ord-92848bcf2cca49f3ad66c760bef2f991
Source dataset
uspto-grants-2001_02
Patent number
US06191280B1

Reaction notes

Loading…