反应详情

温度

160 °C

At 148-156° C., 59.6 g (0.326 mol) of 2,3-difluoro-5-trifluoromethylpyridine were added over a period of 2.5 h to 37.7 g (0.338 mol) of 98.7% pure thiophenol and 2.1 mg (0.01 mol %) of copper powder, and the mixture was stirred at 156-164° C. for 2 hours. After cooling, the residue was taken up in methylene chloride, washed with 0.5 N aqueous sodium hydroxide solution and water, dried over magnesium sulfate and concentrated under reduced pressure. 88.9 g (100% of theory) of the title compound of 24 n D

1. temperatureAfter cooling
2. washwashed with 0.5 N aqueous sodium hydroxide solution and water
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated under reduced pressure