Hydrogen Peroxide → HCID 11043886, compound

Participants

Reaction Conditions

Reaction Steps

At 15-20° C., 8.4 g (0.124 mol) of 50% strength hydrogen peroxide were added over a period of 15 min with stirring to a mixture of 31 g (0.1213 mol) of 3-chloro-2-n-propylthio-5-trifluoromethylpyridine in 150 ml of acetic acid, the temperature increasing to 27° C. over a period of 6 h. The reaction mixture was stirred at 25° C. for 14 h and then poured into ice-water and extracted 3 times with methylene chloride. The organic phase was washed with water and saturated sodium bicarbonate solution, dried and concentrated under reduced pressure, giving 32 g (97.2% of theory) of the title compound of mp. 51-53° C.

Provenance & Evidence