Ketorolac → Ketorolac Tromethamine

Participants

Reaction Conditions

Reaction Steps

Ketorolac acid (10.0 gm, Abbott Laboratories) is dissolved in 75 mL isopropanol. In a separate container, 5.0 gm of tromethamine (Aldrich Chemical Co.) is dissolved in 10 mL distilled water. The two mixtures are combined, mixed for 30 minutes then distilled under atmosphereric conditions. Distillation is continued until approximately one half the volume remains, e.g., about 40 mL. Isopropanol (72 mL) is added and distillation continued until one half the volume remains, whereupon 135 mL of ethyl acetate is added and distillation of the ternary mixture continued. Upon removal of one-half the distillate, the ethyl acetate addition is repeated. When the volume is again brought to one half the starting volume, distillation is terminated. The solution is cooled to 10° C. and the solid ketorolac tromethamine isolated by filtration. The collected solids are dried under vacuum to afford the desired product.

Provenance & Evidence