Ketorolac → Ketorolac Tromethamine

Participants

Reaction Conditions

Reaction Steps

Ketorolac acid (20 gm, Abbott Laboratories) is dissolved in 156.0 gm of isopropanol. A solution of 12.0 gm of tromethamine in 25.0 gm of water is added, and the mixture is heated to 40° C. to a solution. The solution is filtered through a 0.2 micron filter. To the clear filtrate is added 356.0 gm of ethyl acetate, and the ternary solution is distilled under vacuum to approximately half the volume. Another aliquot of 356.0 gm of ethyl acetate is added and the mixture distilled to approximately half the volume and solid starts precipitating out. Ethyl acetate (356.0 gm) is added once more and the mixture distilled to approximately half the volume. The solution is cooled to 10° C. and the solid ketorolac tromethamine is isolated by filtration. The collected solids are dried under vacuum to afford the desired product.

Provenance & Evidence