HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenepropanoyl chloride → N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenepropanoyl chloride | HCID 64801 | — |
| Reactant | 2-Methylpropyl 2-aminopropanoate hydrochloride | HCID 86200109 | — |
| Product | N-(3-phenylpropionyl)-D,L-alanine Isobutyl Ester | HCID 15480461 | — |
Reaction Steps
Following General Procedure A′ above and using 3-phenylpropionyl chloride (Aldrich) and D,L-alanine iso-butyl ester hydrochloride (from Example B′ above), the title compound was prepared as a solid having a melting point of from 51°-54° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191166B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-8bb40a30d46043c7b2cad327416f7031 |
| Source note | uspto-grants-2001_02 |