反应详情

温度

65 °C

A mixture of 0.1 g (0.31 mmol) of 5-bromo-6-chloro-2-(1H-indazol-1-yl)pyrimidine-4-amine (intermediate 5) and 160 μl (1.85 mmol) of cyclopropylmethylamine in 0.5 ml of DMSO in a closed glass tube was stirred for 5 h at 65° C. The reaction mixture was poured onto 20 ml of cold water. The formed white precipitate was filtered, washed several times with water and dried. 0.088 g (79.7%) of the desired compound were obtained.

1. filtrationThe formed white precipitate was filtered
2. washwashed several times with water
3. customdried