(2-Hydroxyphenyl)acetic acid → 2-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

HRID 636105Notes

Reaction equation

HRID 636105 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 11970(2-Hydroxyphenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537176952-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure I′ above and using 2-hydroxyphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-52083ecd963a4cbfbd20ea831cebb8dc
Source dataset
uspto-grants-2001_02
Patent number
US06191166B1

Reaction notes

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