HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 77107697, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 1-[4-amino-5-bromo-6-(ethylamino)pyrimidin-2-yl]-1H-pyrazole-4-carboxylic acid | HCID 77107503 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 77107697 | HCID 77107697 | 65.6% |
Reaction Steps
A mixture of 50 mg (0.15 mmol) of 1-[4-amino-5-bromo-6-(ethylamino)pyrimidin-2-yl]-1H-pyrazole-4-carboxylic acid (example 48), 15 μl (0.17 mmol) of morpholine, 32 μl (0.23 mmol) of triethylamine and 64 mg (0.17 mmol) of HATU in 1 ml of acetonitrile was stirred at room temperature for 10 min. The formed precipitate was filtered, washed with cold water and dried. 39 mg (64.4%) of a white solid were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447095B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-00ac308e671248cf857b52c9f82416a9 |
| Source note | uspto-grants-2016_09 |