2-methylpropyl (2S)-2-aminopropanoate → N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

HRID 636123Notes

Reaction equation

HRID 636123 reaction equation
[C:1]1([S:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[CH2:13][C:14]([OH:16])=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH2:24])[CH:18]([CH3:20])[CH3:19]>>[CH2:17]([O:21][C:22](=[O:26])[C@H:23]([CH3:25])[NH:24][C:14](=[O:16])[CH2:13][C:12]1[CH:11]=[CH:10][S:9][C:8]=1[S:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)[CH:18]([CH3:20])[CH3:19]

Participants

3

Reactant 2

HCID 137435562-methylpropyl (2S)-2-aminopropanoateHCID 54517004(2-Phenylthiothienyl)acetic acid

Product 1

HCID 53734580N-[(2-phenylthiothienyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I′ above, and using (2-phenylthiothienyl)acetic acid and alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-402aa8a9f8694830b7ce5c01d39b3627
Source dataset
uspto-grants-2001_02
Patent number
US06191166B1

Reaction notes

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