p-Tolylacetic acid → N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

HRID 636129Notes

Reaction equation

HRID 636129 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH:13]([CH3:15])[CH3:14]>>[CH2:12]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH:19][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][CH:6]=1)[CH:13]([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 248474p-Tolylacetic acidHCID 137435562-methylpropyl (2S)-2-aminopropanoate

Product 1

HCID 53936136N-[(4-methylphenyl)acetyl]alanine iso-butyl ester

Procedure

Following General Procedure I′ above, and using 4-methylphenylacetic acid (Aldrich) and L-alanine iso-butyl ester (prepared following General Procedure J′ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customprepared

Sources & evidence

ORD record
ord-f81026b401e24a38aaca4bbba81f990d
Source dataset
uspto-grants-2001_02
Patent number
US06191166B1

Reaction notes

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