HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → p-Cyclohexylbenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | (4-Cyclohexylphenyl)methanol | HCID 22492024 | — |
| Reactant | HCID 178418287 | HCID 178418287 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | p-Cyclohexylbenzaldehyde | HCID 119689 | — |
Reaction Steps
18-Crown-6 (Aldrich; 4 molar eq.) and pyridinium chlorochromate (Aldrich; 4 molar eq.) were added together in chloroform and stirred for 20 minutes. 4-Cyclohexylbenzylalcohol (from Example D22 below; 1 molar eq.) was added and stirring continued for 3 hours. Ether was added and the mixture filtered through a plug of silica eluting with ether. The solvent was removed via rotary evaporation. The residue was dissolved in ether and washed with water. The organic layer was dried over Na2SO4, filtered, and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191166B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-ad55b80dab7b4b94806b68929f69acf1 |
| Source note | uspto-grants-2001_02 |