HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate → Methyl N-(N-(3,5Difluorophenylacetyl)-L-alaninyl]-(S)-2-amino3-(2-thienyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate | HCID 10899351 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl N-(N-(3,5Difluorophenylacetyl)-L-alaninyl]-(S)-2-amino3-(2-thienyl)propionate | HCID 10112224 | — |
Reaction Steps
Following General Procedure B and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl (S)-2-amino-3-(2-thienyl)propionate (Bachem), the title compound was prepared as a solid (mp=145-147° C.). The reaction was monitored by tlc (Rf=0.9 in 100% EtOAc) and the product was purified by preparative tlc using EtOAc as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191166B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-d17da8dd8bb84c7c972301c07bb38d65 |
| Source note | uspto-grants-2001_02 |