huagongshe.com
HRID636172

反应详情

EQUATION

反应方程式

HRID 636172 的结构方程式

REACTANTS

反应物

2
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)O
HCID12135350

N-[(3,5-difluorophenyl)acetyl]alanine

C11H11F2NO3

结构：Cl.N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
HCID12636208

Benzyl L-phenylalaninate hydrochloride (1:1)

C16H18ClNO2

PRODUCTS

生成物

1
结构：C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)OCc1ccccc1
HCID10162841

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

Following General Procedure B and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and L-phenylalanine benzyl ester hydrochloride (Bachem), the title compound was prepared as a solid (mp=170-171° C.). The reaction was monitored by tlc (Rf=0.7 in 5% MeOH/methylene chloride) and the product was purified by recrystallization from MeOH.

WORKUP

后处理

  1. customthe product was purified by recrystallization from MeOH