HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate → N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-Methyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate | HCID 7018776 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Product | N-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]-Nepsilon-(tert-butoxycarbonyl)-L-lysine Methyl Ester | HCID 20642604 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and Nε-(tert-butoxycarbonyl)-L-lysine methyl ester (Bachem), the title compound was prepared as an oil. The reaction was monitored by tlc (Rf=0.40 in 50% EtOAc/hexanes) and the product was purified by flash chromatography using 50% EtOAc/hexanes as the eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191166B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-b5e48ef4877c4b7c8b835e618355201c |
| Source note | uspto-grants-2001_02 |