HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → Methyl 1-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]piperidine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Reactant | Methyl Pipecolinate Hydrochloride | HCID 13246231 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | Methyl 1-[N-(3,5-Difluorophenylacetyl)-L-alaninyl]piperidine-2-carboxylate | HCID 9842199 | — |
Reaction Steps
Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (from Example B2 above) and methyl pipecolinate hydrochloride (Aldrich), the title compound was prepared as a solid (mp=114-118° C.). The reaction was monitored by tlc (Rf=0.71 in 10% MeOH/DCM) and the product was purified by acid/base washes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06191166B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-f668eb0e510d4118aada3bc481cdec30 |
| Source note | uspto-grants-2001_02 |