Water → HCID 11697580, compound

Participants

Reaction Steps

To a stirred suspension of 2.1.c (R=Me, P=TBDPS, A=COOCH3) (392 mg, 0.992 mmol) in 10 ml of dry MeOH at room temperature was added dry K2CO3 (30 mg). After 10 min., a second portion of K2CO3 (19 mg) (total: 49 mg, 0.496 mmol) was added. The mixture was stirred for 6 h, then poured into water and Et2O (70 ml:50 ml). The organic layer was separated and the aqueous layer was extracted with Et2O (50 ml×3) and dried over MgSO4. Separation by flash chromatography on silica (isooctane/EtOAc) 9:1), gave hydroxy compound 2.2.c (R=Me, P=TBDPS, A=COOCH3) (344 mg, 98%) as a colorless oil.

Provenance & Evidence