Ammonium Hydroxide → 7-nitro-3,4-dihydro-2H-naphthalen-1-one oxime

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Reaction Steps

7-Nitro-1-tetralone (2.00 g, 10.4 mmol) was dissolved in ethanol (20 mL) and was added to NH4OH (1.64 mL, 16.6 mmol) and NaOAc (1.71 g, 20.8 mmol) in H2O (30 mL). After 2 h at 65° C., the solvent was removed under reduced pressure and the residue was titurated with H2O. The precipitate was removed by filtration and dried under vacuum to give 1.99 g (93%) of the desired material as a white solid. MS (ES-) m/z 205 [M−H]−.

Provenance & Evidence