Cyclopentylamine → HCID 15051904, compound

Participants

Reaction Steps

To 1.5 g of 6-chloro-9-(2′-O-methyl-β-D-ribofuranosyl)-9H-purine and 510 mg of cyclopentylamine, 1.5 ml of triethylamine and 70 ml of ethanol were added. The solution was refluxed with heating for several ten minutes to 8 hours. After washing the residue with water, methanol was added and the solution was concentrated to dryness again. The residue was recrystallized with ethyl acetate to give N6-cyclopentyl-2′-O-methyladenosine (Compound 1). yield: 80%

Provenance & Evidence