Sodium Carbonate → 6-(2-Methylpyridin-4-yl)-1,2,3,4-tetrahydronaphthalen-1-one

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Reaction Conditions

Reaction Steps

To a suspension of 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl 4-methylbenzene-1-sulfonate (1.3 g, 4.4 mmol), 2-methylpyridine-4-boronic acid pinacol ester (800 mg, 3.7 mmol), Na2CO3 (773 mg, 7.3 mmol) and LiCl.H2O (442 mg, 7.3 mmol) in EtOH/H2O/toluene (4.4 mL/2.3 mL/20.0 mL) was added Pd(PPh3)4 (211 mg, 0.2 mmol) at rt under N2. The reaction was stirred at 100° C. overnight. The reaction was filtered and concentrated. Purification by silica gel chromatography (PE:EtOAc=1:1) gave 865 mg (quantitative) of the title compound as a yellow solid. [M+H] Calc'd for C16H15NO, 238. Found, 238.

Provenance & Evidence