HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → 2,3-Dichloro-6-nitrobenzylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2,3-Dichloro-6-nitrobenzyl chloride | HCID 9834663 | — |
| Product | 2,3-Dichloro-6-nitrobenzylamine | HCID 15524239 | 75% |
Reaction Steps
Potassium carbonate and 2 equivalents of phthalimide are ground together and heated to reflux with 2 equivalents of 1,2-dichloro-3-chloromethyl-4-nitrobenzene for three hours. Upon cooling, the substituted benzylphthalimide crystallizes and is filtered in 60-80% yield. 2,3-Dichloro-6-nitrobenzylamine is obtained in a 75-95% yield with acid hydrolysis using hydrochloric acid from the substituted benzylphthalimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194420B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-509bd385bf93474ba5bc09727ef0d5db |
| Source note | uspto-grants-2001_02 |