Ammonia → HCID 9908451, compound

HRID 636398Notes

Reaction equation

HRID 636398 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([C:14]2[C:15]([S:25][CH3:26])=[N:16][N:17]3[C:22](Cl)=[CH:21][C:20]([CH3:24])=[N:19][C:18]=23)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH3:27]>CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([C:14]2[C:15]([S:25][CH3:26])=[N:16][N:17]3[C:22]([NH2:27])=[CH:21][C:20]([CH3:24])=[N:19][C:18]=23)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21254980HCID 21254980, compound

Product 1

HCID 9908451HCID 9908451, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 4, from 3-(4-tert-butyl-benzenesulphonyl)-7-chloro-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine and NH3 in MeOH there was obtained 3-(4-tert-butyl-benzenesulphonyl)-5-methyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidin-7-ylamine as colorless crystals, m.p. >230°.

Sources & evidence

ORD record
ord-f043579fb7404817bcba358102cbd42f
Source dataset
uspto-grants-2001_02
Patent number
US06194410B1

Reaction notes

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