Ammonia → HCID 21255042, compound

HRID 636404Notes

Reaction equation

HRID 636404 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([S:24][CH3:25])[C:10]([S:11]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)(=[O:13])=[O:12])=[C:6]2[N:5]=[C:4]([CH3:26])[CH:3]=1.[NH3:27]>CO>[CH3:26][C:4]1[CH:3]=[C:2]([NH2:27])[N:7]2[N:8]=[C:9]([S:24][CH3:25])[C:10]([S:11]([C:14]3[CH:23]=[CH:22][C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=3)(=[O:13])=[O:12])=[C:6]2[N:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 212550017-Chloro-5-methyl-2-methylsulphanyl-3-(naphthalene-2-sulphonyl)-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 21255042HCID 21255042, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 4, from 7-chloro-5-methyl-2-methylsulphanyl-3-(naphthalene-2-sulphonyl)-pyrazolo[1,5-a]pyrimidine and NH3 in MeOH there was obtained 5-methyl-2-methylsulphanyl-3-(naphthalene-2-sulphonyl)-pyrazolo[1,5-a]pyrimidine-7-ylamine as colorless crystals, m.p.>230°.

Sources & evidence

ORD record
ord-ad683c2fd28a4e2c9f60d46dc9431605
Source dataset
uspto-grants-2001_02
Patent number
US06194410B1

Reaction notes

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