Ammonia → HCID 21254979, compound

HRID 636407Notes

Reaction equation

HRID 636407 reaction equation
[C:1]1([S:7]([C:10]2[C:11]([S:23][CH3:24])=[N:12][N:13]3[C:18](Cl)=[CH:17][C:16]([CH:20]4[CH2:22][CH2:21]4)=[N:15][C:14]=23)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH3:25]>CO>[C:1]1([S:7]([C:10]2[C:11]([S:23][CH3:24])=[N:12][N:13]3[C:18]([NH2:25])=[CH:17][C:16]([CH:20]4[CH2:22][CH2:21]4)=[N:15][C:14]=23)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21254970HCID 21254970, compound

Product 1

HCID 21254979HCID 21254979, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 4, from 3-benzenesulphonyl-7-chloro-5-cyclopropyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine and NH3 in MeOH there was obtained 3-benzenesulphonyl-5-cyclopropyl-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine-7-ylamine as colorless crystals, m.p.>230°.

Sources & evidence

ORD record
ord-8a37d9ccc9d44665a75d18de1150d700
Source dataset
uspto-grants-2001_02
Patent number
US06194410B1

Reaction notes

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