Ammonia → HCID 21254894, compound

HRID 636409Notes

Reaction equation

HRID 636409 reaction equation
Cl[C:2]1[N:7]2[N:8]=[C:9]([S:19][CH3:20])[C:10]([S:11]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)(=[O:13])=[O:12])=[C:6]2[N:5]=[C:4]([CH3:21])[CH:3]=1.[NH3:22]>CO>[CH3:21][C:4]1[CH:3]=[C:2]([NH2:22])[N:7]2[N:8]=[C:9]([S:19][CH3:20])[C:10]([S:11]([C:14]3[S:15][CH:16]=[CH:17][CH:18]=3)(=[O:13])=[O:12])=[C:6]2[N:5]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21254953HCID 21254953, compound

Product 1

HCID 21254894HCID 21254894, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In an analogous manner to that described in Example 4, from 7-chloro-5-methyl-2-methylsulphanyl-3-(thiophene-2-sulphonyl)-pyrazolo[1,5-a]pyrimidine and NH3 in MeOH there was obtained 5-methyl-2-methylsulphanyl-3-(thiophene-2-sulphonyl)-pyrazolo[1,5-a]pyrimidin-7-ylamine as colorless crystals, m.p.>230°.

Sources & evidence

ORD record
ord-8d4fcffba8464a6e86fd6b2aeaccaa4c
Source dataset
uspto-grants-2001_02
Patent number
US06194410B1

Reaction notes

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