Formic Acid → HCID 118597990、化合物

HRID 63643ノート

反応式

HRID 63643 の反応式
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1

参加物

3

反応物 2

HCID 284Formic AcidHCID 124453391,3-Dihydro-2-benzofuran-5-amine

生成物 1

HCID 118597990HCID 118597990、化合物収率 69%

実験手順

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

後処理

  1. temperatureat reflux overnight
  2. concentrationThe reaction was concentrated
  3. extractionextracted with EtOAc
  4. washOrganics were washed with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-7535fa64e1b44f0aa936eef954ce8d4b
出典データセット
uspto-grants-2016_09
特許番号
US09447046B2

反応ノート

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