1-Methylpiperazine → HCID 21254910, compound

Participants

Reaction Steps

0.1 g (1 mmol) of 1-methyl-piperazine in 3 ml of CH2Cl2 was added to a solution of 0.37 g (1 mmol) of 3-benzenesulphonyl-5,7-dichloro-2-methylsulphanyl-pyrazolo[1,5-a]-pyrimidine in 20 ml of CH2Cl2 and stirred at RT for 1 hr. The mixture was poured on to ice-water, adjusted to pH8 with NaHCO3 solution and extracted three times with 30 ml of CH2Cl2. The combined organic phases were dried (MgSO4), filtered and evaporated. Subsequent chromatography (silica gel, CH2Cl2/MeOH 4:1) yielded 0.38 g (86%) of 3-benzenesulphonyl-5-chloro-7-(4-methyl-piperazin-1-yl)-2-methylsulphanyl-pyrazolo[1,5-a]pyrimidine as colorless crystals, m.p.>230°.

Provenance & Evidence