N,N-Dimethyl-1,3-propanediamine → (8-benzenesulphonyl-2-methyl-7-methylsulphanyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl)-N',N'-dimethyl-propan-1,3-diamine

HRID 636460Notes

Reaction equation

HRID 636460 reaction equation
[C:1]1([S:7]([C:10]2[C:11]([S:21][CH3:22])=[N:12][N:13]3[C:18](=O)[NH:17][C:16]([CH3:20])=[N:15][C:14]=23)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:23][N:24]([CH3:29])[CH2:25][CH2:26][CH2:27][NH2:28]>>[C:1]1([S:7]([C:10]2[C:11]([S:21][CH3:22])=[N:12][N:13]3[C:18]([CH:27]([NH2:28])[CH2:26][CH2:25][N:24]([CH3:29])[CH3:23])=[N:17][C:16]([CH3:20])=[N:15][C:14]=23)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 1355493298-benzenesulphonyl-2-methyl-7-methylsulphanyl-3H-pyrazolo[1,5-a][1,3,5]-triazin-4-one

Product 1

HCID 21254964(8-benzenesulphonyl-2-methyl-7-methylsulphanyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl)-N',N'-dimethyl-propan-1,3-diamine

Procedure

In an analogous manner to that described in Example 123 b), from 8-benzenesulphonyl-2-methyl-7-methylsulphanyl-3H-pyrazolo[1,5-a][1,3,5]triazin-4-one and 3-dimethylamino-1-propylamine there was obtained (8-benzenesulphonyl-2-methyl-7-methylsulphanyl-pyrazolo[1,5-a][1,3,5]triazin-4-yl)-N′,N′-dimethyl-propan-1,3-diamine which was converted with HCl/diethyl ether into the corresponding hydrochloride (1:1.75), m.p. 249-250°.

Sources & evidence

ORD record
ord-0ad6784339f34cfd9ff33f4f2544c10d
Source dataset
uspto-grants-2001_02
Patent number
US06194410B1

Reaction notes

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