HRID636475

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID81242

2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-

C10H6ClNO3

结构：CC(C)(C)[Si](OCc1c(Cl)ccc(N)c1Cl)(c1ccccc1)c1ccccc1

HCID10598719

AGN-PC-0N7AEM

C23H25Cl2NOSi

PRODUCTS

生成物

结构：CC(C)(C)[Si](OCc1c(Cl)ccc(NC(=O)CN2C(=O)c3ccccc3C2=O)c1Cl)(c1ccccc1)c1ccccc1

HCID10841518

未命名化合物

收率 92.1%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

To a mixture of 3-amino-1-(tert-butyldiphenylsilyloxy-methyl)-2,6-dichlorobenzene (348 mg) triethylamine (0.15 ml) and dichloromethane (3.5 ml) was added phthalimidoacetyl chloride (186 mg) under ice-cooling, and the mixture was stirred for 1.5 hours at ambient temperature. Water was added thereto, and the resulting precipitates were collected by vacuum filtration and washed with diisopropyl ether to give 1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichloro-3-(phthalimidoacetylamino)benzene (460 mg) as crystals.

WORKUP

后处理

temperaturecooling
customthe resulting precipitates
filtrationwere collected by vacuum filtration
washwashed with diisopropyl ether

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bdee257fae4b4e9485a988d9f25fb7ec
来源数据集: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06194396B1
来源说明: uspto-grants-2001_02

反应 SMILES

[NH2:1][C:2]1[C:3]([Cl:28])=[C:4]([CH2:9][O:10][Si:11]([C:24]([CH3:27])([CH3:26])[CH3:25])([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]([Cl:8])=[CH:6][CH:7]=1.ClCCl.[C:32]1(=[O:46])[N:36]([CH2:37][C:38](Cl)=[O:39])[C:35](=[O:41])[C:34]2=[CH:42][CH:43]=[CH:44][CH:45]=[C:33]12>O>[Si:11]([O:10][CH2:9][C:4]1[C:5]([Cl:8])=[CH:6][CH:7]=[C:2]([NH:1][C:38](=[O:39])[CH2:37][N:36]2[C:35](=[O:41])[C:34]3=[CH:42][CH:43]=[CH:44][CH:45]=[C:33]3[C:32]2=[O:46])[C:3]=1[Cl:28])([C:24]([CH3:25])([CH3:27])[CH3:26])([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1