HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 4-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-1,2-dimethyl-1H-benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-[2,6-dichloro-3-[N-(phthalimidoacetyl)-N-methylamino]benzyloxy]-1,2-dimethyl-1H-benzimidazole | HCID 15462175 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-1,2-dimethyl-1H-benzimidazole | HCID 15462176 | 97.7% |
Reaction Steps
A mixture of 4-[2,6-dichloro-3-[N-(phthalimidoacetyl)-N-methylamino]benzyloxy]-1,2-dimethyl-1H-benzimidazole (405 mg), hydrazine monohydrate (75.4 mg) and ethanol (4.0 ml) was refluxed for 30 minutes. After cooling, the resulting precipitate was filtered off, and the filtrate was concentrated in vacuo to give 4-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-1,2-dimethyl-1H-benzimidazole (300 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194396B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-d255e4f6443a44fb8dcfc505c9907bae |
| Source note | uspto-grants-2001_02 |