反应详情

To a solution of 2-(phenylamino)ethan-1-ol (2.0 g, 14.6 mmol) and imidazole (2.9 g, 43.7 mmol) in DCM (20 mL) was added TBSCl (2.6 g, 16.0 mmol) at r.t., and the reaction was stirred for 2 h. The reaction was diluted with water (50 mL) and extracted with DCM (50 mL×3). Organics were washed with brine (50 mL), dried (Na2SO4), and concentrated. Purification by silica gel chromatography (PE:EtOAc=40:1) gave 3.0 g (82%) of the title compound as a yellow oil.

1. extractionextracted with DCM (50 mL×3)
2. washOrganics were washed with brine (50 mL)
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated
5. customPurification by silica gel chromatography (PE:EtOAc=40:1)