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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 636510Generated: November 2, 2026

Water → HCID 15588674, compound

https://huagongshe.com/reaction/636510

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantMethyl iodideHCID 6328—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 15588673HCID 15588673—
SolventDimethylformamideHCID 6228—
ProductHCID 15588674HCID 1558867494.1%

Reaction Steps

To a suspension of 7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (300 mg) and potassium carbonate (529 mg) in dimethylformamide (3 ml) was added methyl iodide at ambient temperature, and the mixture was stirred for 3 hours under nitrogen atmosphere. Water was added to the reaction mixture, and the resulting precipitates were collected by filtration to give 3-methyl-7-(tetrahydropyran-2-yloxy)-2(3H)-benzoxazolone (299 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06194396B1
Source datasetuspto-grants-2001_02
ORD IDord-cb212c1d66174ac5a3a04f281aa02701
Source noteuspto-grants-2001_02