HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 4-(2-(4-Formylphenyl)ethenyl)pyridine | HCID 5374730 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid | HCID 70245505 | 46.6% |
Reaction Steps
To a solution of 4-[(E)-2-(4-pyridyl)vinyl]benzaldehyde (50 mg) in pyridine (0.025 ml) and ethanol (0.075 ml) was added malonic acid (27.4 mg), and the mixture was refluxed for 7 hours. After cooling, ethyl acetate was added thereto, the resulting precipitates were collected by filtration to give 4-[(E)-2-(4-pyridyl)vinyl]cinnamic acid (28 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194396B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-d6f41240b6ef49eb96bac0acca6767dc |
| Source note | uspto-grants-2001_02 |