HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 7-Methoxy-2-methylbenzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (7-Methoxy-1-benzofuran-2-yl)methanol | HCID 11788606 | — |
| Catalyst | zinc(II)iodide | HCID 9883512 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 7-Methoxy-2-methylbenzofuran | HCID 11275177 | 34.8% |
Reaction Steps
A mixture of 2-hydroxymethyl-7-methoxybenzofuran (300 mg), sodium cyanoborohydride (796 mg) and zinc iodide (809 mg) in dichloroethane (10 ml) was stirred for 2 hours at ambient temperature and then refluxed overnight. Chloroform and water were added to the reaction mixture, and the separated organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by flash chromatography (n-hexane:ethyl acetate=15:1, v/v) to give 7-methoxy-2-methylbenzofuran (95 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194396B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-99fd776611a84181b7ae07d92a263e0e |
| Source note | uspto-grants-2001_02 |