Hydrazine hydrate (1:1) → HCID 21255237, compound

Participants

Reaction Steps

1.9 g (3.6 mmol) of the compound from Example III are suspended in 100 ml of ethanol and treated with 0.5 ml (10 mmol) of hydrazine hydrate. After stirring at RT for 30 min a clear solution is formed. After reflux for 30 min a white precipitate is deposited. The mixture is allowed to cool and the precipitate is filtered off with suction. The solid is purified by chromatography (methylene chloride/ethyl acetate 20+1) and finally recrystallized from ethanol. 0.56 g (44%) is obtained.

Provenance & Evidence