Methanesulfonic Acid → HCID 178505301, compound

Participants

Reaction Conditions

Reaction Steps

Alatrofloxacin zwitterion (25 g wet cake) as either a wet cake or dry product was combined with 10% aqueous ethanol (242 mL), and then methanesulfonic acid (1.9 mL) was added to the slurry to adjust the pH to about 3.5-4.5. The reaction mixture was then heated to reflux, filtered and then concentrated at atmospheric pressure to approximately one-half of its original volume. The solution was then cooled to 0-5° C., and the resulting solids were granulated for 1 hour. After the solids were filtered and washed with ethanol (39 mL), the alatrofloxacin mesylate was dried for 24 hours at 40° C. Alatrofloxacin mesylate (17.7 g), suitable for parenteral formulation, was isolated in 90% yield.

Provenance & Evidence