N-bromobutanimide → HCID 21255158, compound

HRID 636554Notes

Reaction equation

HRID 636554 reaction equation
[F:1][C:2]1[C:7]([C:8]2[N:16]3[C:11]([CH2:12][CH2:13][CH2:14][CH2:15]3)=[C:10]([C:17]#[N:18])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:19]N1C(=O)CCC1=O>>[Br:19][C:9]1[C:10]([C:17]#[N:18])=[C:11]2[N:16]([C:8]=1[C:7]1[C:2]([F:1])=[N:3][CH:4]=[CH:5][CH:6]=1)[CH2:15][CH2:14][CH2:13][CH2:12]2

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 21255195HCID 21255195, compound

Product 1

HCID 21255158HCID 21255158, compoundYield 84.8%

Procedure

2-Bromo-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared as described in Example 9, from 1.6 g of 3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 1.3 g of N-bromosuccinimide. 1.8 g of 2-bromo-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile are thus obtained in the form of beige powder melting at 172° C.

Workup

  1. custom2-Bromo-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared

Sources & evidence

ORD record
ord-5bd063bdd37b45cb9a1df6e34e657f2a
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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