N-bromobutanimide → HCID 21255192, compound

HRID 636555Notes

Reaction equation

HRID 636555 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[N:15]3[C:10]([CH2:11][CH2:12][CH2:13][CH2:14]3)=[C:9]([C:16]#[N:17])[CH:8]=2)=[CH:3][CH:2]=1.[Br:18]N1C(=O)CCC1=O>>[Br:18][C:8]1[C:9]([C:16]#[N:17])=[C:10]2[N:15]([C:7]=1[C:4]1[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=1)[CH2:14][CH2:13][CH2:12][CH2:11]2

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 21255153HCID 21255153, compound

Product 1

HCID 21255192HCID 21255192, compoundYield 84%

Procedure

2-Bromo-3-(4-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared as described in Example 9, from 2.2 g [lacuna] 3-(4-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 2.26 g of N-bromosuccinimide. 2.5 g of 2-bromo-3-(4-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile are thus obtained in the form of orange-beige powder melting at 120° C.

Workup

  1. custom2-Bromo-3-(4-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile is prepared

Sources & evidence

ORD record
ord-0837b60693a94dc8bcd6ef3fd0b63355
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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