N-bromobutanimide → HCID 21255186, compound

HRID 636556Notes

Reaction equation

HRID 636556 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:11]3[CH2:12][S:13][CH2:14][C:10]3=[C:9]([C:15]#[N:16])[CH:8]=2)[CH:2]=1.[Br:17]N1C(=O)CCC1=O>>[Br:17][C:8]1[C:9]([C:15]#[N:16])=[C:10]2[CH2:14][S:13][CH2:12][N:11]2[C:7]=1[C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 67184N-bromobutanimideHCID 13375482HCID 13375482, compound

Product 1

HCID 21255186HCID 21255186, compoundYield 30.7%

Procedure

6-Bromo-5-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile is prepared as in Example 9, from 5 g of 5-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile and 4.1 g of N-bromosuccinimide. 2.07 g of 6-bromo-5-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile are thus obtained in the form of white powder melting at 190° C.

Sources & evidence

ORD record
ord-78cfcade66f24843bf88b32480828e0d
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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