2-Fluoronicotinic acid → HCID 21255121, compound

Participants

Reaction Steps

Ethyl N-(2-fluoronicotinoyl)-3,4,5,6-tetrahydro-2H-1,3-thiazine-4-carboxylate is prepared by the method described in European Patent Application EP 118321, but from 12.5 g of ethyl 3,4,5,6-tetrahydro-2H-1,3-thiazine-4-carboxylate hydrochloride and 13.5 g of 2-fluoronicotinic acid. 8.2 g of ethyl N-(2-fluoronicotinoyl)-3,4,5,6-tetrahydro-2H-1,3-thiazine-4-carboxylate are thus obtained in the form of light-yellow oil, employed as such in the following reaction.

Provenance & Evidence