2-Chloronicotinoyl chloride → HCID 21255137, compound

HRID 636559Notes

Reaction equation

HRID 636559 reaction equation
[CH3:1][CH2:2][O:3][C:4]([CH:6]1[NH:10][CH2:9][S:8][CH2:7]1)=[O:5].Cl.[Cl:12][C:13]1[N:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15](Cl)=[O:16]>>[Cl:12][C:13]1[N:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([N:10]1[CH:6]([C:4]([O:3][CH2:2][CH3:1])=[O:5])[CH2:7][S:8][CH2:9]1)=[O:16]

Participants

3

Reactant 2

HCID 27745412-Chloronicotinoyl chlorideHCID 1301188066223-38-9

Product 1

HCID 21255137HCID 21255137, compoundYield 77.5%

Procedure

Ethyl N-(2-chloronicotinoyl)thiazolidine-4-carboxylate is prepared as described in Example 5, from 23 g of ethyl L-thiazolidine-4-carboxylate hydrochloride and 20.4 g of 2-chloronicotinoyl chloride. 27 g of ethyl N-(2-chloronicotinoyl)thiazolidine-4-carboxylate are thus obtained in the form of a yellow oil, employed crude.

Workup

  1. customEthyl N-(2-chloronicotinoyl)thiazolidine-4-carboxylate is prepared

Sources & evidence

ORD record
ord-b4451a28eea540fa9e9ed9ad1b96fab4
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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