Sulfuric Acid → HCID 21255142, compound

HRID 636561Notes

Reaction equation

HRID 636561 reaction equation
[Cl:1][C:2]1[C:3]([C:18]#[N:19])=[C:4]2[N:9]([C:10]=1[C:11]1[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][CH2:6][CH2:5]2.S(=O)(=O)(O)[OH:21]>>[Cl:1][C:2]1[C:3]([C:18]([NH2:19])=[O:21])=[C:4]2[N:9]([C:10]=1[C:11]1[C:12]([F:17])=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 21255168HCID 21255168, compound

Product 1

HCID 21255142HCID 21255142, compound

Procedure

2-Chloro-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared according to the method described in Example 10, from 1.8 g of 2-chloro-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 30 cm3 of 60% sulphuric acid. 1.3 g of 2-chloro-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is thus obtained in the form of a white powder melting at 191° C.

Workup

  1. custom2-Chloro-3-(2-fluoro-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared

Sources & evidence

ORD record
ord-a7276f503d5040a6a0a8d344bbde3192
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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