HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → HCID 21255184, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 1-(Pyridine-3-carbonyl)piperidine-2-carboxylic acid | HCID 16228264 | — |
| Reactant | Dichloromethane ethylacetate | HCID 21226138 | — |
| Reactant | HCID 86756454 | HCID 86756454 | — |
| Product | HCID 21255184 | HCID 21255184 | — |
Reaction Steps
Methyl 2-methyl-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate is prepared as in Example 1, from 2.56 g of the sodium salt of N-nicotinoylpiperidine-2-carboxylic acid and 7.16 g of 2-bromo-2-methylbutenoate. 1.2 g of methyl 2-methyl-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate are thus obtained in the form of an orange oil (Rf=0.25; thin layer chromatography on silica gel; eluent: 8/2 dichloromethane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06194426B1 |
| Source dataset | uspto-grants-2001_02 |
| ORD ID | ord-35f01fa43cc04a409798ab1de8dea170 |
| Source note | uspto-grants-2001_02 |