HCID 22012115, compound → HCID 21255118, compound

HRID 636568Notes

Reaction equation

HRID 636568 reaction equation
[Cl:1][C:2]1[C:3]([C:18]([O:20][CH3:21])=[O:19])=[C:4]2[N:9]([C:10]=1[C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][C:6](Cl)=[CH:5]2>[Pd]>[Cl:1][C:2]1[C:3]([C:18]([O:20][CH3:21])=[O:19])=[C:4]2[N:9]([C:10]=1[C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH2:8][CH2:7][CH2:6][CH2:5]2

Participants

3

Reactant 1

HCID 22012115HCID 22012115, compound

Product 1

HCID 21255118HCID 21255118, compoundYield 71.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Methyl 2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate is prepared as in Example 39, from 1.4 g of methyl 2,7-dichloro-3-(3-pyridyl)-5,6-dihydroindolizinecarboxylate and 0.28 g of 10% palladium on charcoal. 0.9 g of methyl 2-chloro-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxylate are thus obtained in the form of beige powder melting at 111° C.

Sources & evidence

ORD record
ord-5305f9acd36f42d996d5fd6e05cf1c1b
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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