N-bromobutanimide → HCID 21255115, compound

HRID 636574Notes

Reaction equation

[C:1]([C:4]1[CH:5]=[C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:7]2[C:12]=1[CH2:11][CH2:10][CH2:9][CH2:8]2)(=[O:3])[CH3:2].[Br:19]N1C(=O)CCC1=O>>[C:1]([C:4]1[C:5]([Br:19])=[C:6]([C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[N:7]2[C:12]=1[CH2:11][CH2:10][CH2:9][CH2:8]2)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 67184N-bromobutanimide

HCID 21255159HCID 21255159, compound

Product 1

HCID 21255115HCID 21255115, compoundYield 37.6%

Procedure

1-Acetyl-2-bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine is prepared as described in Example 23, from 1.2 g of 1-acetyl-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine and 1.1 g of N-bromosuccinimide. 0.6 g of 1-acetyl-2-bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine are thus obtained in the form of white crystals melting at 163° C.

Workup

custom1-Acetyl-2-bromo-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine is prepared

Sources & evidence

ORD record: ord-6ace783e64bc4081a3a8fbf5137037c9
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06194426B1

Reaction notes

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