Potassium Hydroxide → HCID 21255164, compound

HRID 636576Notes

Reaction equation

HRID 636576 reaction equation
[C:1]([C:3]1[C:4]([C:18]#[N:19])=[C:5]2[N:10]([C:11]=1[C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:9][CH2:8][CH2:7][CH2:6]2)#[N:2].[OH-:20].[K+]>>[C:1]([C:3]1[C:4]([C:18]([NH2:19])=[O:20])=[C:5]2[N:10]([C:11]=1[C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH2:9][CH2:8][CH2:7][CH2:6]2)#[N:2]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 21255203HCID 21255203, compound

Product 1

HCID 21255164HCID 21255164, compound

Procedure

2-Cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared according to the same method described in Example 11, from 2.12 g of 2-cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 1.69 g of an aqueous solution of potassium hydroxide. 0.72 g of 2-cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide are thus obtained in the form of a white solid melting at 244° C.

Workup

  1. custom2-Cyano-3-(3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared

Sources & evidence

ORD record
ord-200313dd91954cd1a79ca0d802ed3978
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

Loading…