Potassium Hydroxide → HCID 21255202, compound

HRID 636578Notes

Reaction equation

HRID 636578 reaction equation
[CH3:1][C:2]1[C:7]([C:8]2[N:16]3[C:11]([CH2:12][CH2:13][CH2:14][CH2:15]3)=[C:10]([C:17]#[N:18])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[OH-:19].[K+]>>[CH3:1][C:2]1[C:7]([C:8]2[N:16]3[C:11]([CH2:12][CH2:13][CH2:14][CH2:15]3)=[C:10]([C:17]([NH2:18])=[O:19])[CH:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 21255143HCID 21255143, compound

Product 1

HCID 21255202HCID 21255202, compoundYield 87.2%

Procedure

3-(2-Methyl-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared as described in Example 11, from 23.3 g of 3-(2-methyl-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carbonitrile and 33 g of potassium hydroxide. 21.85 g of 3-(2-methyl-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide are thus obtained in the form of a white solid melting at 244° C.

Workup

  1. custom3-(2-Methyl-3-pyridyl)-5,6,7,8-tetrahydroindolizine-1-carboxamide is prepared

Sources & evidence

ORD record
ord-db8a66b047ec49f0b1c0d38486953395
Source dataset
uspto-grants-2001_02
Patent number
US06194426B1

Reaction notes

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